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  But the progression of Parkinson’s disease can vary widely from patient to patient. When evaluating the proteins in the spinal fluids, researchers in this study discovered major differences between subjects. The subjects with Parkinson’s had lower levels of protein biomarkers amyloid beta, tau and, alpha synuclein in their spinal fluid. Researchers also linked specific concentrations of protein biomarkers to specific Parkinson’s symptoms. For example, those with lower concentrations of tau and alpha synuclein had greater motor dysfunction. And patients with low levels of amyloid beta and tau were more likely to have balance issues and postural instability.